PROTAC HER2 degrader-1
Product Specifications
CAS Number
2897640-93-4
Target
Akt, PROTACs, Apoptosis, ERK, EGFR
Related Pathways
PI3K/Akt/mTOR signaling, Angiogenesis, MAPK, Cytoskeletal Signaling, PROTAC, JAK/STAT signaling, Apoptosis, Tyrosine Kinase/Adaptors
Bioactivity
PROTACHER2 degrader-1 is a highly selective HER2 PROTAC degrader with a DC50 of 69 nM and a Dmax of 96%. It effectively inhibits HER2-positive cell proliferation and tumor growth by inducing sustained HER2 degradation and strongly inhibiting downstream pathways (AKT and ERK) . Additionally, PROTACHER2 degrader-1 can induce apoptosis in BT-474 cells and is useful for researching HER2-positive cancers.
Smiles
O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)NCCCCCCCN4CCN(CC4)CCCOC5=CC6=NC=NC(NC7=CC=C(OC=8C=CN9N=CN=C9C8)C(=C7)C)=C6C=C5OC
Molecular Formula
C49H55N11O7
Molecular Weight
910.03
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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