PZ671
Product Specifications
Target
PROTACs, Apoptosis, Bcl-2 Family
Related Pathways
Apoptosis, PROTAC
Bioactivity
PZ671 is a potent PROTAC degrader targeting Bcl-xL, exhibiting an IC50 of 1.3 nM in MOLT-4 cells and a DC50 of 0.9 nM for Bcl-xL. It induces apoptosis in MOLT-4 cells and effectively inhibits tumor growth in MOLT-4 xenograft mice, while quickly restoring transiently reduced platelet counts. PZ671 is applicable in cancer research, including studies on small cell lung cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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