LCL768
Product Specifications
Target
Mitochondrial Metabolism, Mitophagy, PTEN
Related Pathways
Autophagy, Metabolism, PI3K/Akt/mTOR signaling
Bioactivity
LCL768 is a ceramide analogue that attenuates PARKIN succinylation, thereby promoting PARKIN activation and mitophagy. It induces the accumulation of CerS1-mediated endogenous C18-ceramide in mitochondria, facilitating mitophagy through DRP1 activation via C644 site nitrosylation. Additionally, LCL768 alters mitochondrial metabolism, depleting fumarate and inhibiting tumor growth. Furthermore, it ameliorates sensorimotor deficits in neurodegenerative diseases such as ALS.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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