PBD dimer-4
Product Specifications
CAS Number
1821339-88-1
Target
Others, DNA Alkylator/Crosslinker
Related Pathways
Others, DNA Damage/DNA Repair
Bioactivity
PBD dimer-4 (Compound 7) is a C1-substituted PBD dimer. This compound exhibits high DNA-binding affinity, effective DNA cross-linking ability, and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM) . PBD dimer-4 serves as a payload in the ADC drug Loncastuximab tesirine, utilized for treating various cancer types.
Smiles
O(CCCO[C@@H]1[C@@]2(N(CC1)C(=O)C=3C(N=C2)=CC(OC)=C(OC)C3)[H])[C@@H]4[C@@]5(N(C(=O)C=6C(N=C5)=CC(OC)=C(OC)C6)CC4)[H]
Molecular Formula
C31H36N4O8
Molecular Weight
592.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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