N-Deacetyl-N-formylcolchicine
Product Specifications
CAS Number
7411-12-3
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine binding site on tubulin. It exhibits antiproliferative activity against various cancer cell lines, with IC50 values ranging from 32.61 to 100.28 nM. This compound inhibits microtubule polymerization, blocking cell division, inducing apoptosis in cancer cells, and suppressing cellular migration. N-Deacetyl-N-formylcolchicine shows potential for research in lung cancer and other solid tumors.
Smiles
O(C)C1=C2C=3C([C@@H](NC=O)CCC2=CC(OC)=C1OC)=CC(=O)C(OC)=CC3
Molecular Formula
C21H23NO6
Molecular Weight
385.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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