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DHC-286

Product Specifications

CAS Number

2920443-08-7

Target

Molecular Glues

Related Pathways

PROTAC

Bioactivity

DHC-286 is a molecular glue degrader that targets GSPT1. It recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, facilitating its ubiquitination and subsequent degradation via the proteasome, which induces cytotoxic effects. DHC-286 holds potential for cancer research.

Smiles

O=C(NCC=1C=CC=CC1C(F)(F)F)COC2=CC=C3C(=O)N(CC3=C2)C4C(=O)NC(=O)CC4

Molecular Formula

C23H20F3N3O5

Molecular Weight

475.42

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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