DHC-286
Product Specifications
CAS Number
2920443-08-7
Target
Molecular Glues
Related Pathways
PROTAC
Bioactivity
DHC-286 is a molecular glue degrader that targets GSPT1. It recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, facilitating its ubiquitination and subsequent degradation via the proteasome, which induces cytotoxic effects. DHC-286 holds potential for cancer research.
Smiles
O=C(NCC=1C=CC=CC1C(F)(F)F)COC2=CC=C3C(=O)N(CC3=C2)C4C(=O)NC(=O)CC4
Molecular Formula
C23H20F3N3O5
Molecular Weight
475.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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