TC-2559 free base
Product Specifications
CAS Number
189274-78-0
Target
STAT|||AChR
Related Pathways
Stem Cells|||JAK/STAT signaling|||Neuroscience
Bioactivity
TC-2559 free base is an ?4?2 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 0.18 ?M. It shows weaker agonistic effects on ?4 subunit nAChR genotypes (?2?4, ?4?4, and ?3?4 receptors), with EC50 values ranging from 10-30 ?M. In vitro, TC-2559 free base enhances dopamine cell firing in the rat ventral tegmental area (VTA), increasing the excitability and bursting activity of VTA dopaminergic neurons. It also inhibits STAT3 to exert anti-inflammatory effects, alleviates mechanical allodynia in mice, and improves cognitive deficits in rats. TC-2559 free base is utilized in neuropathic pain research.
Smiles
C(=C/CCNC)\C=1C=C(OCC)C=NC1
Molecular Formula
C12H18N2O
Molecular Weight
206.28
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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