KMT9-IN-1
Product Specifications
CAS Number
2625406-61-1
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and an ethyl ester prodrug of compound 7b. Inside cells, KMT9-IN-1 releases the active form 7b through the action of esterases. It specifically associates with the KMT9 target within cells, leading to a reduction in H4K12me1 levels. KMT9-IN-1 exhibits antitumor activity against colon cancer and can be employed in research on prostate cancer and hepatocellular carcinoma.
Smiles
O[C@H]1[C@H](N2C=3C(C=C2)=C(NC)N=CN3)C[C@H](CN(CC[C@@H](C(OCC)=O)N)CCCNCCC4=CC(F)=C(OC5=CC=C(Cl)C=C5)C=C4)[C@H]1O
Molecular Formula
C36H47ClFN7O5
Molecular Weight
712.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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