APH02174
Product Specifications
CAS Number
3065494-66-5
Target
IRAK, PROTACs, Interleukin
Related Pathways
Immunology/Inflammation, PROTAC, NF-κB
Bioactivity
APH02174 is a highly selective and orally active IRAK4PROTAC degrader, with a DC50 of 4.01 nM in THP-1 cells. It blocks inflammatory signaling by inhibiting IL-6 release and is applicable for researching inflammatory diseases such as psoriasis and rheumatoid arthritis.
Smiles
C(N1CCC2(CC=3C(O2)=CC(=C(NC(=O)C=4C=5C(OC4)=CC=CN5)C3)N6CCC(CO)CC6)CC1)[C@H]7CC[C@H](OCC#CC8=C9C(N(C(=O)N9C)C%10C(=O)NC(=O)CC%10)=CC=C8)CC7
Molecular Formula
C49H55N7O8
Molecular Weight
870
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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