Osunprotafib hydrochloride
Product Specifications
CAS Number
2986745-48-4
Target
Phosphatase
Related Pathways
Metabolism
Bioactivity
Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM) . It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.
Smiles
FC=1C(=C(O)C=C2C1C[C@H](NCCC(C)C)CC2)N3CC(=O)NS3(=O)=O.Cl
Molecular Formula
C17H25ClFN3O4S
Molecular Weight
421.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6270198-01 0.1 mL
TRIC-A (Trimeric Intracellular Cation Channel Type A, TRICA, Transmembrane Protein 38A, TMEM38A) (PE)
Sign In for Pricing
View Details 
MBS6270198-02 5x 0.1 mL
TRIC-A (Trimeric Intracellular Cation Channel Type A, TRICA, Transmembrane Protein 38A, TMEM38A) (PE)
Sign In for Pricing
View Details 
MBS1488729-01 0.05 mg
Rabbit anti-Human HLA class II histocompatibility antigen, DR alpha chain polyclonal Antibody, HRP conjugated
Sign In for Pricing
View Details