RIPK1-IN-32
Product Specifications
Target
Interleukin, NF-κB, p38 MAPK, TNF, RIP kinase
Related Pathways
NF-κB, MAPK, Apoptosis, Immunology/Inflammation
Bioactivity
RIPK1-IN-32 is an RIPK inhibitor with anti-inflammatory properties. It inhibits nitric oxide (NO) release, with an IC50 of 3.26 μM. Additionally, RIPK1-IN-32 disrupts the RIPK1/NF-κB/MAPK signaling pathway, preventing nuclear translocation of p65 and c-fos, leading to reduced expression of TNF-α and IL-6 and significantly alleviating acute liver injury related to sepsis. This compound is useful for studies on acute liver injury and sepsis.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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