RIPK1-IN-32

Product Specifications

Target

Interleukin|||NF-?B|||p38 MAPK|||TNF|||RIP kinase

Related Pathways

NF-?B|||MAPK|||Apoptosis|||Immunology/Inflammation

Bioactivity

RIPK1-IN-32 is an RIPK inhibitor with anti-inflammatory properties. It inhibits nitric oxide (NO) release, with an IC50 of 3.26 ?M. Additionally, RIPK1-IN-32 disrupts the RIPK1/NF-?B/MAPK signaling pathway, preventing nuclear translocation of p65 and c-fos, leading to reduced expression of TNF-? and IL-6 and significantly alleviating acute liver injury related to sepsis. This compound is useful for studies on acute liver injury and sepsis.