What is the catalog number for SOS1-IN-20?

The catalog number for SOS1-IN-20 is T211427.

What sizes are available for SOS1-IN-20?

SOS1-IN-20 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does SOS1-IN-20 come in?

SOS1-IN-20 is available in 2 different pack sizes.

Is SOS1-IN-20 in stock?

SOS1-IN-20 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SOS1-IN-20?

SOS1-IN-20 is manufactured by Molfinity.

What is the estimated delivery time for SOS1-IN-20?

Estimated delivery time for SOS1-IN-20 is approximately 10 business day(s), depending on your location.

SOS1-IN-20

Product Specifications

Target

Raf, Ras, Potassium Channel

Related Pathways

MAPK, Membrane transporter/Ion channel

Bioactivity

SOS1-IN-20 (Compound 12f) is an orally active inhibitor of SOS1, exhibiting an IC50 of 5.11 nM against KRASG12C::SOS1. It prevents KRAS activation and its downstream signaling by disrupting the KRAS-SOS1 interaction. In PC-9 cells, it shows an IC50 of 253 nM for p-ERK, while its IC50 for the hERG channel is 16.71 μM. SOS1-IN-20 also inhibits tumor cell proliferation, displaying antitumor activity.