SOS1-IN-20
Product Specifications
Target
Raf|||Ras|||Potassium Channel
Related Pathways
MAPK|||Membrane transporter/Ion channel
Bioactivity
SOS1-IN-20 (Compound 12f) is an orally active inhibitor of SOS1, exhibiting an IC50 of 5.11 nM against KRASG12C::SOS1. It prevents KRAS activation and its downstream signaling by disrupting the KRAS-SOS1 interaction. In PC-9 cells, it shows an IC50 of 253 nM for p-ERK, while its IC50 for the hERG channel is 16.71 ?M. SOS1-IN-20 also inhibits tumor cell proliferation, displaying antitumor activity.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/390881968868868141/T211427
Available Sizes
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