MI891
Product Specifications
CAS Number
2530027-77-9
Target
Others|||Cytochromes P450
Related Pathways
Others|||Metabolism
Bioactivity
MI891 is a highly selective PXR antagonist (IC50= 3.76 ?M, Kd= 1.7 ?M) and inverse agonist (IC50= 6.1 ?M) . It selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin-induced PXR activation and can be utilized in research on metabolic and other diseases.
Smiles
O=C(N)C1=CC(=CC=C1Cl)CN2N=NC(=C2)C3=C(N=C4C(F)=CC(F)=CN43)C=5C=CC(Cl)=CC5
Molecular Formula
C23H14Cl2F2N6O
Molecular Weight
499.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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