MI891
Product Specifications
CAS Number
2530027-77-9
Target
Others, Cytochromes P450
Related Pathways
Others, Metabolism
Bioactivity
MI891 is a highly selective PXR antagonist (IC50= 3.76 μM, Kd= 1.7 μM) and inverse agonist (IC50= 6.1 μM) . It selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin-induced PXR activation and can be utilized in research on metabolic and other diseases.
Smiles
O=C(N)C1=CC(=CC=C1Cl)CN2N=NC(=C2)C3=C(N=C4C(F)=CC(F)=CN43)C=5C=CC(Cl)=CC5
Molecular Formula
C23H14Cl2F2N6O
Molecular Weight
499.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A13764-3-Dylight550 100 µg
Anti-TMEM30B Antibody Picoband®, Dylight550 Conjugate
Sign In for Pricing
View Details LC407147 20 µg
C13orf31 (LACC1) (NM_153218) Human Over-expression Lysate
Sign In for Pricing
View Details 
NBP3-21033 100 µg
Rabbit Monoclonal TIMP-2 Antibody (TIMP2/8193R) - Azide and BSA Free
Sign In for Pricing
View Details