IDO1-IN-27
Product Specifications
Target
TNF|||Interleukin|||Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Immunology/Inflammation|||Apoptosis|||Metabolism
Bioactivity
IDO1-IN-27 (Compound I-1) is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), displaying an IC50 of 0.3951 ?M against recombinant hIDO1. It also inhibits hIDO1 expression in HeLa cells with an EC50 of 62 nM. By reducing the mRNA expression of pro-inflammatory factors (TNF-?, IL-6, and IL-1?), IDO1-IN-27 effectively stimulates T cell proliferation and simultaneously inhibits the growth of LLC cells.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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