STAT3/NF-κB-IN-1
Product Specifications
Target
STAT, Bcl-2 Family, NF-κB, Caspase, Apoptosis
Related Pathways
Proteases/Proteasome, JAK/STAT signaling, Apoptosis, NF-κB, Stem Cells
Bioactivity
STAT3/NF-κB-IN-1 is a potent inhibitor of STAT3 and NF-κB, exhibiting IC50 values of 5.86 μM for STAT3 and 4.22 μM for NF-κB in 4 T1 cells. It induces apoptosis by upregulating key apoptotic regulators (caspases-3, 9, Bax) and downregulating Bcl-2 expression. STAT3/NF-κB-IN-1 shows significant anticancer activity against breast cancer cell lines and can reduce tumor volume in vivo. It is applicable for research in breast cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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