PI3Kδ-IN-24
Product Specifications
CAS Number
3051829-20-7
Target
PI3K, Akt, Apoptosis
Related Pathways
PI3K/Akt/mTOR signaling, Apoptosis, Cytoskeletal Signaling
Bioactivity
PI3Kδ-IN-24 is a selective inhibitor of PI3Kδ with an IC50 value of 0.1 nM. It exhibits significant antiproliferative effects on cancer cell lines that overexpress PI3Kδ. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. This compound is applicable for cancer research, particularly in diffuse large B-cell lymphoma (DLBCL) .
Smiles
N([C@H](C(=O)N1CCN(C)CC1)C)C=2C3=C(C=CC(=N3)C=4C=C(C(OC5=CC=CC=C5)=O)C(OC)=NC4)N=CN2
Molecular Formula
C28H29N7O4
Molecular Weight
527.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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