KBD4466
Product Specifications
CAS Number
3023713-87-0
Target
TLR|||Interleukin|||IFNAR
Related Pathways
Immunology/Inflammation
Bioactivity
KBD4466 is a potent oral inhibitor of TLR7 and TLR8, with IC50 values of 0.9 nM and 2.8 nM, respectively. This compound effectively suppresses the inflammatory cytokines IL-6 and IFN-?. KBD4466 has shown to improve disease progression and increase survival rates in the BXSB/MpJ mouse model of systemic lupus erythematosus (SLE) . It is suitable for research into autoimmune diseases.
Smiles
C(F)(F)(F)[C@@]12[C@@](C1)(CN(C2)C=3C4=C(C(C#N)=CC3)N=CC=C4)C=5OC(=NN5)C6CCN(C)CC6
Molecular Formula
C24H23F3N6O
Molecular Weight
468.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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