STING-IN-16
Product Specifications
CAS Number
2982807-58-7
Target
Apoptosis|||STING|||ROS|||Interleukin|||IFNAR
Related Pathways
Apoptosis|||Immunology/Inflammation
Bioactivity
STING-IN-16 is an inhibitor of STING, with an IC50 value of 44 nM in humans and 32 nM in mice. This compound effectively suppresses the activation of the STING pathway in both human and mouse cells. STING-IN-16 aids in restoring kidney mitochondrial function, inhibits the production of reactive oxygen species (ROS), and reduces apoptosis. It exhibits significant anti-inflammatory effects in vivo and is a valuable tool for researching autoimmune and autoinflammatory diseases.
Smiles
O=C(NC1=CNC=2C=CC(Cl)=CC21)N3CC4=CC=C(C=C4CC3)C=5C=CC(OC)=CC5
Molecular Formula
C25H22ClN3O2
Molecular Weight
431.91
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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