Pro-FTY
Product Specifications
CAS Number
3064707-13-4
Target
LPL Receptor, STAT
Related Pathways
GPCR/G Protein, JAK/STAT signaling, Stem Cells
Bioactivity
Pro-FTY is an anticancer prodrug of FTY720 and acts as a sphingosine-1-phosphate (S1P) inhibitor. It specifically inhibits S1P signaling in cancer cells via a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly reduces the survival of breast cancer cells, including multidrug-resistant cells and organoids resistant to Paclitaxel or Doxorubicin. Additionally, pro-FTY effectively suppresses tumor growth in xenograft mouse models of 4T1 cells or organoids while avoiding lymphopenia.
Smiles
[N-]=[N+]=NC=1C(=CC(=CC1C(C)C)COC(=O)NC(CO)(CO)CCC2=CC=C(C=C2)CCCCCCCC)C(C)C
Molecular Formula
C33H50N4O4
Molecular Weight
566.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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