Mesutoclax
Product Specifications
CAS Number
2760536-87-4
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM) . It inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and can be utilized in cancer research.
Smiles
C(C1=C(CC(C)(C)CC1)C2=CC=C(Cl)C=C2)N3[C@H](C)CN(CC3)C4=CC(OC=5C=C6C(=NC5)NC=C6)=C(C(NS(=O)(=O)C7=CC(N(=O)=O)=C(NC[C@H]8COCCO8)C=C7)=O)C=C4
Molecular Formula
C45H50ClN7O8S
Molecular Weight
884.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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