CH091138
Product Specifications
Target
PROTACs, Apoptosis, Ras
Related Pathways
Apoptosis, PROTAC, MAPK
Bioactivity
CH091138 is a potent and selective KRASG12D PROTAC degrader, exhibiting a DC50 value of 148.3 nM in HeLa cells and 469.8 nM in AsPC-1 cells. It selectively targets both exogenous and endogenous KRASG12D through the VHL-mediated ubiquitin-proteasome system, without affecting KRASWT or other KRAS mutants (G12C/G12S/G12V) . CH091138 demonstrates significant antitumor activity by inducing apoptosis (apoptosis) in tumor cells and is applicable for research in pancreatic and colon cancers.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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