What is the catalog number for USP7-IN-18?

The catalog number for USP7-IN-18 is T211314.

What sizes are available for USP7-IN-18?

USP7-IN-18 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does USP7-IN-18 come in?

USP7-IN-18 is available in 2 different pack sizes.

Is USP7-IN-18 in stock?

USP7-IN-18 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures USP7-IN-18?

USP7-IN-18 is manufactured by Molfinity.

What is the estimated delivery time for USP7-IN-18?

Estimated delivery time for USP7-IN-18 is approximately 10 business day(s), depending on your location.

USP7-IN-18

Product Specifications

CAS Number

3052223-40-9

Target

DUB, DNA Methyltransferase, MDM-2/p53

Related Pathways

Chromatin/Epigenetic, DNA Damage/DNA Repair, Ubiquitination, Cell Cycle/Checkpoint, Apoptosis

Bioactivity

USP7-IN-18 (Compound X21) serves as a novel USP7 inhibitor by directly suppressing enzyme activity and modulating downstream pathways, including the newly identified PCLAF target. At concentrations of 0.25-1 μM for 24 hours, it exhibits inhibitory effects. USP7-IN-18 effectively reduces proliferation in leukemia (RS4;11) and colon cancer (MC38/CT26.WT) cells at 0.01-100 μM over 72 hours. It demonstrates high selectivity for USP7 at 2.5 μM within 0.5 hours, surpassing eight other deubiquitinating enzymes. SPR analysis shows that at 1.95-2000 nM for 3 minutes, the compound binds the catalytic domain of USP7 with a KD value of 4.9 μM.