USP7-IN-18
Product Specifications
CAS Number
3052223-40-9
Target
DUB, DNA Methyltransferase, MDM-2/p53
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Ubiquitination, Cell Cycle/Checkpoint, Apoptosis
Bioactivity
USP7-IN-18 (Compound X21) serves as a novel USP7 inhibitor by directly suppressing enzyme activity and modulating downstream pathways, including the newly identified PCLAF target. At concentrations of 0.25-1 μM for 24 hours, it exhibits inhibitory effects. USP7-IN-18 effectively reduces proliferation in leukemia (RS4;11) and colon cancer (MC38/CT26.WT) cells at 0.01-100 μM over 72 hours. It demonstrates high selectivity for USP7 at 2.5 μM within 0.5 hours, surpassing eight other deubiquitinating enzymes. SPR analysis shows that at 1.95-2000 nM for 3 minutes, the compound binds the catalytic domain of USP7 with a KD value of 4.9 μM.
Smiles
O=C1N(C(=O)C2C1C2(C)C)CC=3SC=4C(=NC=CC4C5=CC(Cl)=C6C=CC=CC6=C5OC7CCNCC7)C3
Molecular Formula
C30H28ClN3O3S
Molecular Weight
546.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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