PRMT5-MTA-IN-5

PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible inhibitor of the PRMT5-MTA complex (PRMT5•MTA) with an IC50 value of 1.15 nM. It effectively blocks arginine methylation, impedes the processing of ribosomal RNA, and suppresses the expression of proteins related to the cell cycle. PRMT5-MTA-IN-5 significantly inhibits the proliferation of tumor cells lacking MTAP and shows potential for research into MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers.