AR antagonist 12
Product Specifications
CAS Number
2902679-42-7
Target
Androgen Receptor
Related Pathways
Endocrinology/Hormones
Bioactivity
AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist, demonstrating IC50 values of 119.3 μM for wt-AR and 98.2 μM for AR-F877L. It induces a dose- and time-dependent reduction in the protein levels of AR, AR-v7, and PSA. AR antagonist 12 exhibits anticancer activity, making it useful in the study of Enzalutamide-resistant prostate cancer.
Smiles
C([C@](C(NC=1C=C(C(F)(F)F)C(C#N)=NC1)=O)(C)O)N2CC3N(C(C2)CC3)C4=CC=C(C#N)C=C4
Molecular Formula
C24H23F3N6O2
Molecular Weight
484.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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