Tubulin-IN-51
Product Specifications
CAS Number
849550-36-3
Target
Apoptosis|||Microtubule Associated
Related Pathways
Apoptosis|||Cytoskeletal Signaling
Bioactivity
Tubulin-IN-51 is an orally active tubulin inhibitor with an IC50 of 31 nM. It promotes tubulin polymerization in vitro and does not competitively bind with Paclitaxel. Tubulin-IN-51 inhibits the binding of Vinblastine to tubulin and suppresses tumor growth in various nude mouse xenograft models, including those using A549 human non-small cell lung cancer (NSCLC) cells and U87-MG human glioblastoma.
Smiles
N([C@@H](C(F)(F)F)C)C1=C(C(Cl)=NC=2N1N=CN2)C3=C(F)C=C(OCCCNC)C=C3F
Molecular Formula
C18H18ClF5N6O
Molecular Weight
464.82
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K3189408 1.0 µg DNA
Csta sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details 
GTR15364033 1 Vial
Lentiviral human SLC7A4 sgRNA gene knockout kit - Lentiviral human SLC7A4 sgRNA gene knockout kit (100)
Sign In for Pricing
View Details GTR15376979 1 Vial
Lentiviral human BRDT sgRNA gene knockout kit - Lentiviral human BRDT sgRNA gene knockout kit (plasmid)
Sign In for Pricing
View Details 