Tubulin-IN-51
Product Specifications
CAS Number
849550-36-3
Target
Apoptosis|||Microtubule Associated
Related Pathways
Apoptosis|||Cytoskeletal Signaling
Bioactivity
Tubulin-IN-51 is an orally active tubulin inhibitor with an IC50 of 31 nM. It promotes tubulin polymerization in vitro and does not competitively bind with Paclitaxel. Tubulin-IN-51 inhibits the binding of Vinblastine to tubulin and suppresses tumor growth in various nude mouse xenograft models, including those using A549 human non-small cell lung cancer (NSCLC) cells and U87-MG human glioblastoma.
Smiles
N([C@@H](C(F)(F)F)C)C1=C(C(Cl)=NC=2N1N=CN2)C3=C(F)C=C(OCCCNC)C=C3F
Molecular Formula
C18H18ClF5N6O
Molecular Weight
464.82
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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