PROTAC PDE4 degrader-1
Product Specifications
Target
Interleukin|||PDE|||PROTACs|||TNF
Related Pathways
PROTAC|||Metabolism|||Apoptosis|||Immunology/Inflammation
Bioactivity
PROTACPDE4 degrader-1 (Compound 9m) is an orally active, selective PDEC4 PROTAC degrader with a DC50 of 41.98 ?M. It effectively inhibits the secretion of pro-inflammatory cytokines, such as TNF-? and IL-6, and significantly reduces pulmonary inflammation in a mouse model of LPS-induced acute lung injury (ALI) .
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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