PROTAC PDE4 degrader-1
Product Specifications
Target
Interleukin, PDE, PROTACs, TNF
Related Pathways
PROTAC, Metabolism, Apoptosis, Immunology/Inflammation
Bioactivity
PROTACPDE4 degrader-1 (Compound 9m) is an orally active, selective PDEC4 PROTAC degrader with a DC50 of 41.98 μM. It effectively inhibits the secretion of pro-inflammatory cytokines, such as TNF-α and IL-6, and significantly reduces pulmonary inflammation in a mouse model of LPS-induced acute lung injury (ALI) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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