DASK1
Product Specifications
CAS Number
3064086-31-0
Target
ASK, PROTACs
Related Pathways
PROTAC, Apoptosis
Bioactivity
DASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1) . It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.
Smiles
O=C(NC1=NC(=CC=C1)C2=NN=CN2C(C)C)C3=CC(NC(=O)CCC(=O)NCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6)=C(F)C=C3F
Molecular Formula
C38H38F2N10O8
Molecular Weight
800.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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