TR antagonist 2
Product Specifications
CAS Number
1073179-55-1
Target
Thyroid hormone receptor (THR)
Related Pathways
Endocrinology/Hormones
Bioactivity
TR antagonist 2 (Compound 10a) is a competitive inhibitor of thyroid hormone receptors (TR?/?) with an IC50 of 47 nM. It works by competitively binding to the ligand-binding domain of the receptor with triiodothyronine (T3), thereby blocking the formation of the receptor-coactivator complex, inhibiting target gene transcription, and reducing thyroid hormone-mediated metabolic effects. TR antagonist 2 holds potential for research into hyperthyroidism (such as Graves' disease) and thyrotoxicosis.
Smiles
O=C(NNC(=O)CC1=CCN(C2=CC=C(C=C2)N(=O)=O)CC1)NC3=CC=CC(=C3)C(F)(F)F
Molecular Formula
C21H20F3N5O4
Molecular Weight
463.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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