Neuroprotective agent 11
Product Specifications
CAS Number
3081915-81-0
Target
MDM-2/p53, COX, Caspase, NO Synthase
Related Pathways
Neuroscience, Apoptosis, Immunology/Inflammation, Proteases/Proteasome
Bioactivity
Neuroprotective agent 11 (Compound 1a) is an orally active polyphenolic compound that offers significant protection against cerebral ischemia. Its primary activities include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarct size, and improving behavioral symptoms in mice with cerebral ischemia. The mechanism involves downregulating inflammatory factors (iNOS, COX-2) and apoptotic proteins (cleaved-Caspase3, p53) . Neuroprotective agent 11 is applicable for research in ischemia-related brain diseases, such as ischemic stroke.
Smiles
O[C@H]1[C@@H](C=2C(O[C@@H]1C3=CC(O)=C(O)C=C3)=C(CC)C(O)=CC2O)C4=C5C(C[C@H](O)[C@H](O5)C6=CC(O)=C(O)C=C6)=C(O)C=C4O
Molecular Formula
C32H30O12
Molecular Weight
606.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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