COX-2-IN-55
Product Specifications
CAS Number
2649115-80-8
Target
Calcium Channel, VEGFR, Caspase
Related Pathways
Metabolism, Tyrosine Kinase/Adaptors, Membrane transporter/Ion channel, Apoptosis, Angiogenesis, Proteases/Proteasome
Bioactivity
COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC) . Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.
Smiles
O=S(=O)(NC=1C=CC=C(N)C1)C2=CC=C(C=C2)N3N=C(C=C3C=4C=C(C=CC4C)C)C(F)(F)F
Molecular Formula
C24H21F3N4O2S
Molecular Weight
486.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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