A2073
Product Specifications
CAS Number
2834742-70-8
Target
Akt, NF-κB, p38 MAPK, PI3K
Related Pathways
Cytoskeletal Signaling, NF-κB, PI3K/Akt/mTOR signaling, MAPK
Bioactivity
A2073 is a flavonoid derivative that inhibits the proliferation of erythroleukemia cells by inducing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways. It forms stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1) . In a zebrafish xenograft tumor model, A2073 demonstrates significant anti-tumor cell proliferation activity while maintaining low toxicity. A2073 is suitable for research in acute erythroleukemia.
Smiles
O[C@]12[C@]([C@@H](C[C@H]1OC(CN3CCCCC3)=O)C4=CC=CC=C4)(OC=5C2=C(OC)C=C(OC)C5)C6=CC=C(OC)C=C6
Molecular Formula
C33H37NO7
Molecular Weight
559.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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