PVTX-405
Product Specifications
CAS Number
2991021-08-8
Target
Molecular Glues, IKZF, Potassium Channel
Related Pathways
PROTAC, Immunology/Inflammation, Membrane transporter/Ion channel
Bioactivity
PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 μM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.
Smiles
C(N1CCC2(C=3C(OC2)=C4C(=CC3)C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)CC1)C6=CC(=CC=C6)C7=CN(C)N=C7
Molecular Formula
C30H31N5O4
Molecular Weight
525.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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