KRASG12D-IN-5
Product Specifications
CAS Number
2933935-13-6
Target
Ras
Related Pathways
MAPK
Bioactivity
KRASG12D-IN-5 (Compound 241) is an orally active KRAS (G12D) inhibitor with an IC50 of 11 nM. It demonstrates potent anticancer activity without significant cytotoxicity to BxPC-3 cells (wild-type), KRAS-mutant AsPC-1 cells (G12D), and MIAPaCa-2 cells (G12C), with CC50 values of 10.37, 0.76, and 0.3 μM, respectively. KRASG12D-IN-5 is applicable in cancer studies, including lung, pancreatic, and colorectal cancers.
Smiles
C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=C(O)C3)C=CC(F)=C4C#C)N5CC6(C(F)F)NC(C5)CC6)[C@@]78N(C[C@H](F)C7)CCC8
Molecular Formula
C34H31F5N6O2
Molecular Weight
650.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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