What is the catalog number for KB-0118?

The catalog number for KB-0118 is T211196.

What sizes are available for KB-0118?

KB-0118 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does KB-0118 come in?

KB-0118 is available in 2 different pack sizes.

KB-0118 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures KB-0118?

KB-0118 is manufactured by Molfinity.

What is the estimated delivery time for KB-0118?

Estimated delivery time for KB-0118 is approximately 10 business day(s), depending on your location.

KB-0118

Product Specifications

CAS Number

2648377-08-4

Target

Interleukin, STAT, Epigenetic Reader Domain

Related Pathways

Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Immunology/Inflammation

Bioactivity

KB-0118 (BBC0115) is an inhibitor targeting the BET bromodomain. It selectively binds to BRD2 and BRD4, with dissociation constants (Kd) of 36.7 μM for BRD2 BD1 and 47.4 μM for BRD4 BD1, while not binding to BRD3. KB-0118 suppresses the secretion of pro-inflammatory cytokines such as TNF, IL-1β, and IL-23a, and selectively inhibits Th17 cell differentiation. The compound regulates Th17-driven inflammation through the epigenetic suppression of BRD4, as evidenced by the downregulation of STAT3 and BRD4 target genes. Additionally, KB-0118 exhibits immunomodulatory effects in inflammatory bowel disease (IBD) models.