CFON-026
Product Specifications
CAS Number
2941611-57-8
Target
BTK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
CFON-026 is a selective, orally active, non-covalent BTK inhibitor with an IC50 of 0.27 nM. It demonstrates significant antitumor activity against wild-type BTK (TMD8 and REC-1) as well as all clinically relevant BTK resistance mutations (BTKC481S, T474I, L528W, and V416L) . CFON-026 induces complete tumor regression in the TMD8 xenograft mouse model. This compound is applicable for research into hematologic cancers, such as chronic lymphocytic leukemia and Waldenström's macroglobulinemia.
Smiles
NC=1C=2N3C([C@]4(C[C@](NC(=O)CCCCC\C=C\C3=CN1)(CCC4)[H])[H])=NC2C5=CC=C(C(NC6=CC(C#N)=CC=N6)=O)C=C5
Molecular Formula
C33H34N8O2
Molecular Weight
574.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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