KIN-8741
Product Specifications
CAS Number
2941104-53-4
Target
C-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
KIN-8741 is a highly selective and orally active Type IIb c-Met inhibitor. It exhibits broad-spectrum activity against c-Met kinase mutations. KIN-8741 demonstrates antitumor activity in non-small cell lung cancer models with MET gene amplification and exon 14 deletion. It is applicable in research on c-Met-driven cancers, particularly advanced tumors harboring MET exon 14 skipping mutations and acquired resistance mutations.
Smiles
O(C=1C2=C(C=C(OC)C(O[C@H](CO)C)=C2)N=CC1)C3=C(F)C=C(NC(=O)C=4C(OC)=CC=NC4)C=C3F
Molecular Formula
C26H23F2N3O6
Molecular Weight
511.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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