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NMT-IN-8

Product Specifications

CAS Number

2765258-26-0

Target

Others

Related Pathways

Others

Bioactivity

NMT-IN-8 (Compound Ex.129) is an orally active and highly selective N-myristoyltransferase (NMT) inhibitor with an IC50 value of less than 10 nM. It binds to the peptide binding pocket of NMT, blocking the enzyme-catalyzed protein N-myristoylation, thereby disrupting key pathways such as protein transport, signal transduction, and viral replication. NMT-IN-8 shows promise for research in oncology (including MYC-dependent cancers and B-cell lymphoma) and infectious diseases (such as malaria, HIV, and rhinovirus infections) .

Smiles

C(NC(=O)C1CN(C1)C2=NC(=NC=C2Cl)N3[C@@H](C)CNCC3)(C)(C)C=4N5C(=NC4)C=CC=C5

Molecular Formula

C23H29ClN8O

Molecular Weight

468.98

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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