MET Transcription-IN-1
Product Specifications
CAS Number
3082125-66-1
Target
Apoptosis, c-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
MET Transcription-IN-1 (Compound C3) is an orally active inhibitor of MET transcription that efficiently binds to and stabilizes the G-quadruplex in the MET promoter region, thereby inhibiting c-Met expression. It can overcome resistance caused by specific c-Met mutations and effectively inhibits tumor cell proliferation, migration, and invasion, inducing cell cycle arrest and apoptosis. This compound exhibits antitumor activity and is applicable in the study of tumors such as non-small cell lung cancer.
Smiles
N1=CC=CC=2C1=C3N=CC=CC3=C4NC(=NC24)C=5OC(=CC5)C=6C=CC=C(OC)C6
Molecular Formula
C24H16N4O2
Molecular Weight
392.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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