INCB126503
Product Specifications
CAS Number
2640089-88-7
Target
FGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
INCB126503 is an orally active and selective inhibitor of FGFR2/3, with IC50 values of 70 nM for FGFR1, 2.1 nM for FGFR2, 1.2 nM for FGFR3, 0.92 nM for FGFR3-V555L, 0.85 nM for FGFR3-V555M, and 64 nM for FGFR4. This compound inhibits FGFR signaling in vivo without causing hyperphosphatemia and demonstrates antitumor efficacy in xenograft models with FGFR3 genetic alterations.
Smiles
O(C)C=1C=C2C(C(=NN2)C=3C=CC(=NC3)N4C[C@]5(N(CC4)C[C@H](O)C5)[H])=NC1C6=C(C)C(C)=CC=C6
Molecular Formula
C27H30N6O2
Molecular Weight
470.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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