FC-14369
Product Specifications
CAS Number
3066894-28-5
Target
HIV Protease, PROTACs
Related Pathways
Proteases/Proteasome, PROTAC, Microbiology/Virology
Bioactivity
FC-14369 is a PROTAC degrader targeting the HIV-1Nef protein (HIV-1Nef protein) with a DC50 value of 160 nM. By means of its bifunctional structure, FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase, facilitating Nef ubiquitination and proteasomal degradation. This action restores the expression of cell surface CD4 and MHC-I, thereby inhibiting HIV-1 replication. FC-14369 is applicable in the study of HIV infection and AIDS.
Smiles
O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCNC(=O)COC4=CC=C(C=C4)CCC=5C(=NN(C6=NC=7C=C(Cl)C=CC7N6)C5O)C=8C=CC(=CC8)C(F)(F)F)C3C2=O)CC1
Molecular Formula
C42H34ClF3N8O7
Molecular Weight
855.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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