2-Ethylhexyl (E) -3- (4- (methoxy-d3) phenyl) acrylate
Product Specifications
CAS Number
2734919-82-3
Target
Thyroid hormone receptor (THR) |||Others|||Cytochromes P450|||Androgen Receptor|||Estrogen Receptor/ERR
Related Pathways
Others|||Endocrinology/Hormones|||Metabolism
Bioactivity
2-Ethylhexyl (E) -3- (4- (methoxy-d3) phenyl) acrylate is the deuterated form of Octinoxate. Octinoxate (Octyl methoxycinnamate) acts as an agonist of thyroid hormone receptors, leading to a reduction in triiodothyronine (T3) and thyroxine (T4) levels, as well as the transcription levels of type II deiodinase (deio2) related genes in Japanese Medaka. Commonly used as a safe ultraviolet (UV) filter in aquatic environments, Octinoxate inhibits CYP1A1 and CYP1B1, and influences hyaluronic acid (HA) metabolism in human keratinocytes through a PI3K pathway-dependent manner. It also exhibits both anti-estrogenic and anti-androgenic effects in vitro and in vivo.
Smiles
C(=C/C(OCC(CCCC)CC)=O)\C1=CC=C(OC([2H])([2H])[2H])C=C1
Molecular Formula
C18H26O3
Molecular Weight
293.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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