XSJ110
Product Specifications
CAS Number
203923-65-3
Target
Apoptosis, Topoisomerase
Related Pathways
DNA Damage/DNA Repair, Apoptosis
Bioactivity
XSJ110 is a potent irreversible inhibitor of topoisomerase I (Topo I) with an IC50 value of 0.133 μM. It halts the topoisomerization process of DNA, leading to double-strand breaks and inducing cell cycle arrest in the G0/G1 phase, ultimately causing apoptosis in tumor cells. XSJ110 shows potential for research in ampullary carcinoma (AC) .
Smiles
C(CC)(=O)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC=CC5
Molecular Formula
C23H20N2O5
Molecular Weight
404.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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