What is the catalog number for MAO-B-IN-45?

The catalog number for MAO-B-IN-45 is T211128.

What sizes are available for MAO-B-IN-45?

MAO-B-IN-45 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does MAO-B-IN-45 come in?

MAO-B-IN-45 is available in 2 different pack sizes.

Is MAO-B-IN-45 in stock?

MAO-B-IN-45 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MAO-B-IN-45?

MAO-B-IN-45 is manufactured by Molfinity.

What is the estimated delivery time for MAO-B-IN-45?

Estimated delivery time for MAO-B-IN-45 is approximately 10 business day(s), depending on your location.

MAO-B-IN-45

Product Specifications

CAS Number

3069915-36-9

Target

Microtubule Associated, Monoamine Oxidase, ROS, Glutathione Peroxidase, Beta Amyloid, Ferroptosis

Related Pathways

Metabolism, Immunology/Inflammation, Cytoskeletal Signaling, Neuroscience, Apoptosis

Bioactivity

MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3xTg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.